Projects

The main genotyping projects that CIMBA has been involved in to date are listed below. Further details on the results of these projects can be found in the Publications section.

  • 2014-2016 – Genotyping on the custom OncoArray, as part of the Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative:
      • BRCA1: >533,000 SNPs genotyped in 15,694 carriers
      • BRCA2: >533,000 SNPs genotyped in 10,988 carriers

  • 2011-2013 – Genotyping on the custom iCOGS array, as part of the Collaborative Oncological Gene-environment Study (COGS) Consortium:
      • BRCA1: >200,000 SNPs genotyped in 15,170 carriers
      • BRCA2: >200,000 SNPs genotyped in 8,211 carriers
          Approximately 51,000 of these SNPs were selected on the basis of the BRCA1/2 GWAS.

  • 2012 – Genotyping on the Exome array:
    • BRCA1: >247,000 SNPs genotyped in 2,079 carriers

  • 2009-2010 – GWAS in BRCA1 mutation carriers:
    • Stage 1: >500,000 SNPs genotyped in 2727 carriers
    • Stage 2: 89 SNPs genotyped in 5,986 carriers
  • 2009-2010 – GWAS in BRCA2 mutation carriers:
    • Stage 1: >500,000 SNPs genotyped in 1703 carriers
    • Stage 2: 85 SNPs genotyped in 2486 carriers
    • 2005-2011 – Candidate SNP studies for >100 SNPs