Projects

CIMBA is currently involved in the Confluence project, a multi-consortium breast cancer GWAS project funded by NCI.

Previous genotyping projects that CIMBA has been involved in to date are listed below. Further details on these projects can be found in the Publications section and some summary results are available using the OncoArray and iCOGS links below.

If you require access to individual level data from the iCOGS or OncoArray projects, you will need to make an
application
to the CIMBA Data Access Co-Ordination Committee.



  • 2014-2016 – Genotyping on the custom OncoArray, as part of the Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative:
      • BRCA1: >533,000 SNPs genotyped in 15,694 carriers
      • BRCA2: >533,000 SNPs genotyped in 10,988 carriers
      • Summary level statistics from the main CIMBA OncoArray (2017) project are available here.

      Summary level statistics from the CIMBA BRCA1/BCAC Triple-Negative meta-analysis (2020) are available here.

    Summary level statistics from the BRCA1/BRCA2 breast cancer survival analysis (2020) are available here.

    Summary level statistics from the BCAC-CIMBA Case-only analysis (2021) are available here.

  • 2011-2013 – Genotyping on the custom iCOGS array, as part of the Collaborative Oncological Gene-environment Study (COGS) Consortium:
      • BRCA1: >200,000 SNPs genotyped in 15,170 carriers
      • BRCA2: >200,000 SNPs genotyped in 8,211 carriers
          Approximately 51,000 of these SNPs were selected on the basis of the BRCA1/2 GWAS.
      • Summary results from the iCOGS project can be downloaded here.

  • 2012 – Genotyping on the Exome array:
  • BRCA1: >247,000 SNPs genotyped in 2,079 carriers
  • 2009-2010 – GWAS in BRCA1 mutation carriers:
    • Stage 1: >500,000 SNPs genotyped in 2727 carriers
    • Stage 2: 89 SNPs genotyped in 5,986 carriers
    • 2009-2010 – GWAS in BRCA2 mutation carriers:
      • Stage 1: >500,000 SNPs genotyped in 1703 carriers
      • Stage 2: 85 SNPs genotyped in 2486 carriers
      • 2005-2011 – Candidate SNP studies for >100 SNPs